+38 057 707 73 80
  1. Home
  2. Institutes and Centers
  3. Research institute of experimental and clinical medicine
Research institute of experimental and clinical medicine

About us

Research Institute of Experimental and Clinical Medicine aims at improving the quality of research, providing innovative research technologies, performing research in the fields of fundamental and clinical medicine, developing and implementing novel medical approaches for diagnosis, prevention and treatment of diseases at Kharkiv National Medical University.

Contacts
Address:
street Trinkler, 6, Kharkiv
Email:
ndi.ekm@knmu.edu.ua
Director
Prokopiuk Vоlоdimir
Candidate of Medical Sciences
Leading researcher
Posokhov Yevgen
Doctor of Chemical Sciences
Collective:

Structure:

Projects and Research Grants
  • Grant issued by the U.S. Civilian Research & Development Foundation (CRDF) for a joint research project with the National Institute of Allergy and Infectious Diseases (USA). Topic: Establishing TB Portal of Mycobacterium tuberculosis cases from Kharkiv, Ukraine (Sub-investigator – Anton Tkachenko);
  • Grant issued by the U.S. Civilian Research & Development Foundation (CRDF) for a joint research project with the National Institute of Allergy and Infectious Diseases (USA). Topic: Establishing TB Portal of Mycobacterium tuberculosis cases from Ukraine (Sub-investigators – Anton Tkachenko and Anatolii Onishchenko);
  • Research project funded by the Ministry of Health of Ukraine using the funds provided by the state budget entitled “Research of Efficiency, Mechanisms of Action and Safety of Use of Orthovanadate Nanoparticles of Rare Earth Elements for Optimization of Radiation Therapy in the Conditions of Oncopathology”, state registration number 0121U110920 (principal investigator – Anton Tkachenko; investigators – Anatolii Onishchenko, Volodymyr Prokopyuk, Yevgen Posokhov);
  • Research project funded by the Ministry of Health of Ukraine using the funds provided by the state budget entitled “Elaboration of the Strategy for Prevention and Treatment of Toxic Liver Damage in Patients with Multidrug-Resistant TB in Chemotherapy and Tobacco Smoking”, state registration number 0120U102042 (investigator – Anton Tkachenko);
  • Research project № 0120U105451 funded by the National Research Foundation of Ukraine entitled “Development of Intelligent Technologies for Assessing the Epidemic Situation to Support Decision-Making in the Population Biosafety Management” (investigator – Anton Tkachenko);
  • Research project entitled “Biochemical Mechanisms for the Induction of Intestinal Inflammation and the Ways of its Correction”, state registration number 0120U102645 (investigators – Anton Tkachenko and Anatolii Onishchenko).
International Collaboration

Research Institute of Experimental and Clinical Medicine has been collaborating with Tarsus University (Tarsus, Turkey) and All Saints University College of Medicine (Kingstown, Saint Vincent and the Grenadines). The collaboration focuses on the study of efficacy, mechanisms of action and biosafety of rare-element orthovanadate nanoparticles as enhancement agents for the radiation therapy of oncopathology.

Collaboration within Ukraine

Research Institute of Experimental and Clinical Medicine collaborates with:

  • Institute for Scintillation Materials of the National Academy of Sciences of Ukraine;
  • Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine;
  • V.N. Karazin Kharkiv National University;
  • Taras Shevchenko National University of Kyiv.
Major publications
  1. Maksimchuk PO, Hubenko KO, Seminko VV, Karbivskii VL, Tkachenko AS, Onishchenko AI, Prokopyuk VY, Yefimova SL. High antioxidant activity of gadolinium-yttrium orthovanadate nanoparticles in cell-free and biological milieu. Nanotechnology. 2021 Nov 8;33(5). doi: 10.1088/1361-6528/ac31e5. PMID: 34673550.
  2. Pogozhykh D, Posokhov Y, Myasoedov V, Gubina-Vakulyck G, Chumachenko T, Knigavko O, Polikarpova H, Kalashnyk-Vakulenko Y, Sharashydze K, Nakonechna O, Prokopyuk V, Onishchenko A, Tkachenko A. Experimental Evaluation of Food-Grade Semi-Refined Carrageenan Toxicity. Int J Mol Sci. 2021 Oct 16;22(20):11178. doi: 10.3390/ijms222011178. PMID: 34681837; PMCID: PMC8539956.
  3. Onishchenko A, Myasoedov V, Yefimova S, Nakonechna O, Prokopyuk V, Butov D, Kökbaş U, Klochkov V, Maksimchuk P, Kavok N, Tkachenko A. UV Light-Activated GdYVO4:Eu3+ Nanoparticles Induce Reactive Oxygen Species Generation in Leukocytes Without Affecting Erythrocytes In Vitro. Biol Trace Elem Res. 2021 Aug 13. doi: 10.1007/s12011-021-02867-z. Epub ahead of print. PMID: 34386912.
  4. Tkachenko A, Kot Y, Prokopyuk V, Onishchenko A, Bondareva A, Kapustnik V, Chumachenko T, Perskiy Y, Butov D, Nakonechna O. Food additive E407a stimulates eryptosis in a dose-dependent manner. Wien Med Wochenschr. 2021 Aug 12. doi: 10.1007/s10354-021-00874-2. Epub ahead of print. PMID: 34383224.
  5. Tkachenko A, Pogozhykh D, Onishchenko A, Myasoedov V, Podrigalo L, Klochkov V, Chumachenko T, Prokopyuk V, Yefimova S, Gubina-Vakulyck G, Kavok N, Butov D, Andrieiev A, Polikarpova H, Nakonechna O. Gadolinium Orthovanadate GdVO4:Eu3+ Nanoparticles Ameliorate Carrageenan-Induced Intestinal Inflammation. J Pharm Nutr Sci 2021;11(1):40-48.DOI: https://doi.org/10.29169/1927-5951.2021.11.06
  6. Tkachenko A, Onishchenko A, Posokhov Y, Roshal A, Myasoedov V, Nakonechna O. Changes in cell membranes of white blood cells treated with a common food additive E407a. Turk J Biochem 2021. https://doi.org/10.1515/tjb-2020-0129
  7. Tkachenko AS, Kot YG, Kapustnik VA, Myasoedov VV, Makieieva NI, Chumachenko TO, Onishchenko AI, Lukyanova YM, Nakonechna Semi-refined carrageenan promotes reactive oxygen species (ROS) generation in leukocytes of rats upon oral exposure but not in vitro. Wien Med Wochenschr. 2021 Mar;171(3-4):68-78. doi: 10.1007/s10354-020-00786-7.
  8. Tkachenko A, Onishchenko A, Roshal A, Nakonechna O, Chumachenko T, Posokhov Y. Effects of semi-refined carrageenan (food additive E407a) on cell membranes of leukocytes assessed in vivo and in vitro. Med Glas (Zenica) 2021; 18(1):176-183doi: 10.17392/1213-21.
  9. Tkachenko A, Onishchenko A, Klochkov V, Kavok N, Nakonechna O, Yefimova S, Korniyenko Y, Ryshchenko I, Posokhov Y. The impact of orally administered gadolinium orthovanadate GdVO4:Eu3+ nanoparticles on the state of phospholipid bilayer of erythrocytes. Turk J Biochem 2020; 45(4): 389–395. DOI: https://doi.org/10.1515/tjb-2019-0427
  10. TkachenkoAS, Gubina-VakulyckGI, KlochkovVK, KavokNS, OnishchenkoAI, GorbachTV, Nakonechna OA. Experimental evaluation of the impact of gadolinium orthovanadate GdVO4:Eu3+ nanoparticles on the carrageenan-induced intestinal inflammation. Acta Medica (Hradec Králové) 2020; 63(1): 18–24 https://doi.org/10.14712/18059694.2020.11