The Department was established in 1921 along with the establishment of the Faculty of Odontology at the Kharkiv Medical Institute (KhMI). Initially, the Department was called the Department of Conservative Dentistry, later the Department of Conservative Dentistry with Propaedeutic Odontology. Professor Ehei Nakhmenovich (Yefim, Yukhim Mikhailovich) Gofung was the founder and first head of the Department.

The first staff members: dentist Gofung E.N,, head of the department; dentist Schwartzer E.B., senior assistant; dentists Pokrovska V. A., Volshonok S. S., Sokolovsky M. V. and Levina F. I., ragistrars; laboratory assistant Rabinovich V. I. dentist Vilkomirskaya A. L., administrative manager; Dubrovin I. F., Shevchenko T. M.

After the reorganization, the Faculty of Dentistry was restored at KhMI (1978). In December 1979, the Department of Therapeutic Dentistry resumed its activities. From 1979 to 2004 the department was headed by Professor Halyna Fedorivna Katurova. The teaching staff created the educational, scientific and medical base of the department.

Since 2004, Department is headed by Professor Yevhen Mykolayovych Ryabokon, MD, a KhMI graduate.