The department of Faculty Therapy of Kharkiv National Medical University was founded in 1877. Professor Lashkevych Valerian Grigorovych became its head. In 1895–1896 the building of the faculty therapeutic clinic was found on the basis of of Kharkiv Regional Clinical Hospital. Professor Lashkevich V.G scientific activity included two major directions: the damage of the internal organs in patients with syphilis and various disorders of the nervous system. He wrote 26 scientific works.

From 1888 to 1903 the department was headed by Professor Obolensky Ivan Mykolayovych. The diseases of digestive tract, metabolic and infectious diseases were investigated under his leadership.

Professor Openhovsky Fedir Mechislavovych was head of the department of Faculty Therapy during 1903–1914. He delivered a lectures and made a practical courses of percussion and auscultation. The subject of his research was nerve physiology, pharmacology and experimental pathology. From 1914 to 1918 the department was being headed by Zhebrovsky E.A. and Kakovsky A.F.

Professor Shatilov Petro Ivanovych was head of the department from 1918 to 1921. During this period the main current topics of scientific research was: tuberculosis, pneumonia, anatomical and functional features of the cardiovascular system, the study of cardiac and vascular noises, the physical registration of the pulse wave and its changes in various diseases of the heart and vessels, as well as epidemiology and immunology of typhus.

From 1924 to 1940 the department was being headed by I.I. Feinschmidt. Scientific activity of the department included research of respiratory diseases, including pulmonary tuberculosis, early diagnosis and rational therapy of circulatory failure, diabetes. The methodology for determining and calculating the main change was developed. In 1925, a student scientific group was founded at the department of Faculty Therapy.

Professor Chernikov Evgen Abramovich was head of the department from 1941–1946. During this period the issues of etiopathogenesis and treatment of “septic angina”, wound sepsis, clinics and treatment of inflammatory injuries of the chest was studied. As well as that issues of heart disease, rheumatism, metabolic disorders and physiotherapy treatments (balneotherapy) was in the field of scientific interests of Professor Chernikov E.A.

From 1946 to 1966 the department was being headed by Professor Steinberg Solomon Yakovych. His scientific group investigated the clinical significance of asymmetry of blood pressure, theory and early diagnostic of atherosclerosis, hypertension and coronary insufficiency, clinical significance of the microelement metabolism. Professor Steinberg S.Y. proposed a method of clinical plethysmography.

From 1966 to 1982 the department was being headed by Professor Pocheptsov Valentyn Georgijovych, Honored Worker of the Higher School of Ukraine. During that time, new effective treatment methods in cardiology, gastroenterology and allergology were developed. Professor Pocheptsov V.G. was a supervisor of 2 doctoral theses and 26 candidate dissertations.

From 1982 to 2009 Honored Scientist of Ukraine, Doctor of Medical Sciences, Professor Khvorostinka Volodymyr Mykolayovych headed the department. Further optimizations of the educational process, improvement of scientific work, use of new methods of diagnostic of internal diseases were made under his direction. The main lines of scientific problems were the study of chronic liver diseases, chronic cholecystitis, chronic bowel diseases, improvement of their early diagnosis and pathogenetic treatment. The etiological and pathogenetic factors and features of chronic diseases of the digestive tract in relation to the immune parameters and the system of adaptive hormones were studied. Professor Khvorostinka V.N. wrote more than 560 scientific works, among which – 30 textbooks, manuals and monographs; 33 authors’ certificates and patents; 48 methodological recommendations.

Professor Zhuravlyova Larysa Volodymyrivna is head of the department from 2009 year.

Since 2018 department was renamed to Department of Internal Medicine № 3 and Endocrinology.